RAF Typhoon fighter aircraft have conducted a mission with French aircraft in a coordinated attack against an underground arms cache in Syria operated by the IS group, according to the UK's MoD.
The location, identified by reconnaissance, was believed to be storing arms and explosives, the statement said, and was located in mountains just to the north of the ancient city of Palmyra in central Syria.
"The RAF jets used precision-guided Paveway IV munitions to hit a number of entry passages leading to the site... initial indications are that the target was engaged successfully," the MoD said.
There was no sign of any civilian impact in the operation late on Saturday and each participating jet returned safely, the defence officials confirmed.
The British jets were assisted by a Voyager aerial refuelling aircraft.
The Islamic State group - alternatively referred to as Daesh - established jihadist rule over parts of Iraq and Syria until 2019.
"This operation demonstrates British leadership, and resolve to stand shoulder to shoulder with our allies, to stamp out any revival of the terrorist group and their violent and radical beliefs in the area," UK Defence Secretary the Defence Secretary stated.
RAF aircraft have performed surveillance missions over Syria to "deter any efforts to regroup" of the group following its defeat at the battle of Baghuz in the year 2019, the MoD reported.
"I want to thank all the members of British forces who took part in this strike for their skill and their bravery," Healey added. "Including them were numerous British troops on duty over Christmas and New Year. This operation, to eliminate dangerous terrorists who endanger our way of life, demonstrates how UK forces are ready to step up, all year round, keeping Britain secure within its borders and strong abroad."
In December, the US military conducted what it called a "major assault" against Daesh sites in Syria, following an attack resulted in the deaths of two American soldiers and a civilian linguist in Palmyra.
The U.N. says IS still maintains between 5,000 and 7,000 militants in Syria and Iraq.